Article
Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer.
The Journal of biological chemistry - 27 Sept 2002
Kim Soyoun, Zagozdzon Radoslaw, Meisler Alan, Baleja James D, Fu Yigong, Avraham Shalom, Avraham Hava
Abstract excerpt
Our previous studies demonstrated that Csk homologous kinase (CHK) acts as a negative growth regulator of human breast cancer through inhibition of ErbB-2/neu-mediated Src family kinase activity (Bougeret, C., Jiang, S., Keydar, I., and Avraham, H. (2001) J. Biol. Chem. 276, 33711-33720. The interaction between the CHK SH2 domain and Tyr(P)(1248) of the ErbB-2 receptor has been shown to be specific and critical...
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