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Article

Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.

Cancer letters - 28 Oct 2010

Meyer Sara E, Peace Belinda E, Bahassi El Mustapha, Kavanaugh Gina M, Wagh Purnima K, Robbins Susan B, Yin Moying, Wells Susanne I, Zinser Glendon M, Stambrook Peter J, Waltz Susan E

Abstract excerpt

The CHEK2 (Chk2 in mice) polymorphic variant, CHEK2*1100delC, leads to genomic instability and is associated with an increased risk for breast cancer. The Ron receptor tyrosine kinase is overexpressed in a large fraction of human breast cancers. Here, we asked whether the low penetrance Chk2*1100...

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Source

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Identifiers

PMID: 20434834
DOI: 10.1016/j.canlet.2010.04.011
PMCID: PMC2914152

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20434834-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice.PMID 20434834Read ↗

The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.Semantic proximity Read ↗

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.Semantic proximity Read ↗

Association Between CHEK2*1100delC and Breast Cancer: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.Semantic proximity Read ↗

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American populationSemantic proximity Read ↗

The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.Semantic proximity Read ↗

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.Semantic proximity Read ↗

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