The influence of drug treatment on the maintenance of schistosome genetic diversity.

doi:10.1007/s002850100092

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Article

The influence of drug treatment on the maintenance of schistosome genetic diversity.

Journal of mathematical biology - 1 Jul 2001

Feng Z, Curtis J, Minchella D J

Abstract excerpt

Drug treatment of patients with schistosomiasis may select for drug-resistant parasites. In this article, we formulate a deterministic model with multiple strains of schistosomes (helminth parasites with a two-host life cycles) in order to explore the role of drug treatment in the maintenance of a polymorphism of parasite strains that differ in their resistance levels. The basic reproductive numbers for all...

Topics

Animals
Biological Evolution
Computer Simulation
Drug Resistance
Host-Parasite Interactions
Humans
Models, Biological
Numerical Analysis, Computer-Assisted
Phenotype
Polymorphism, Genetic
Schistosoma
Schistosomiasis
Snails
Time Factors

Source

Open in PubMed

Identifiers

PMID: 12120867
DOI: 10.1007/s002850100092

Provenance

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