Article
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
The Journal of biological chemistry - 27 Sept 2002
Chen Fusheng, Gu YongJun, Hasegawa Hiroshi, Ruan Xueying, Arawaka Shigeki, Fraser Paul, Westaway David, Mount Howard, St George-Hyslop Peter
Abstract excerpt
The presenilin 1 (PS1) and presenilin 2 (PS2) proteins are necessary for proteolytic cleavage of the amyloid precursor protein (APP) within its transmembrane domain. One of these cleavage events (termed gamma-secretase) generates the C-terminal end of the Abeta-peptide by proteolysis near residue 710 or 712 of APP(770). Another event (termed gamma-like or epsilon-secretase cleavage) cleaves near residue 721 at...
Topics
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Blotting, Western
- Catalysis
- Cell Line
- Endopeptidases
- Enzyme Activation
- Humans
- Mass Spectrometry
- Membrane Proteins