Article
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2002
Moehlmann Tobias, Winkler Edith, Xia Xuefeng, Edbauer Dieter, Murrell Jill, Capell Anja, Kaether Christoph, Zheng Hui, Ghetti Bernardino, Haass Christian, Steiner Harald
Abstract excerpt
The Alzheimer's disease (AD)-associated presenilin (PS) proteins are required for the gamma-secretase cleavages of the beta-amyloid precursor protein and the site 3 (S3) protease cleavage of Notch. These intramembrane cleavages release amyloid-beta peptide (Abeta), including the pathogenic 42-aa variant (Abeta(42)), as well as the beta-amyloid precursor protein and the Notch intracellular domains (AICD, NICD)....
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