Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.

Abstract excerpt

Neurofibromatosis type 2 is an autosomal dominant disorder characterized by tumors, predominantly schwannomas, in the nervous system. It is caused by mutations in the gene NF2, encoding the growth regulator schwannomin (also known as merlin). Mutations occur throughout the 17-exon gene, with most resulting in protein truncation and undetectable amounts of schwannomin protein. Pathogenic mutations that result in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytoskeletal Proteins
• Share to Integrin beta1