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Article

Both constitutive and inducible prostaglandin H synthase affect dermal wound healing in mice.

Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2002

Laulederkind Stanley J F, Thompson-Jaeger Sandra, Goorha Sarita, Chen Qingshan, Fu Amina, Rho Jae-Young, Ballou Leslie R, Raghow Rajendra

Abstract excerpt

In an attempt to define the roles of prostaglandin H synthase 1 (PGHS-1, cyclooxygenase-1, COX-1) and prostaglandin H synthase 2 (PGHS-2, cyclooxygenase-2, COX-2) in wound healing, we investigated the healing of incisional dermal wounds in wild-type, PGHS-1 null, and PGHS-2 null mice. We measured tensile strength of the wounds, levels of PGHS-1 and PGHS-2 mRNA in the wound site, and histologic markers for the...

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Identifiers

PMID: 12118094
DOI: 10.1097/01.lab.0000020407.98665.98

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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