Microarray-Based Identification of <i>htrA</i> , a <i>Streptococcus pneumoniae</i> Gene That Is Regulated by the CiaRH Two-Component System and Contributes to Nasopharyngeal Colonization

Abstract excerpt

Nasopharyngeal carriage is the reservoir from which most disease with Streptococcus pneumoniae arises. Survival as a commensal in this environment is likely to require a set of adaptations distinct from those needed to cause disease, some of which may be mediated by two-component signal transduction systems (TCSTS). We examined the contributions of nine pneumococcal TCSTS to the process of nasopharyngeal...

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