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The<i>Streptococcus pneumoniae cia</i>Regulon: CiaR Target Sites and Transcription Profile Analysis

16 Dec 2002

Abstract excerpt

The ciaR-ciaH system is one of 13 two-component signal-transducing systems of the human pathogen Streptococcus pneumoniae. Mutations in the histidine protein kinase CiaH confer increased resistance to beta-lactam antibiotics and interfere with the development of genetic competence. In order to identify the genes controlled by the cia system, the cia regulon, DNA fragments targeted by the response regulator CiaR...

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PMID: 12486041
DOI: 10.1128/jb.185.1.60-70.2003

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