The CiaR Response Regulator in Group B<i>Streptococcus</i>Promotes Intracellular Survival and Resistance to Innate Immune Defenses

Abstract excerpt

Group B Streptococcus (GBS) is major cause of invasive disease in newborn infants and the leading cause of neonatal meningitis. To gain access to the central nervous system (CNS), GBS must not only subvert host defenses in the bloodstream but also invade and survive within brain microvascular endothelial cells (BMEC), the principal cell layer composing the blood-brain barrier (BBB). While several GBS determinants...

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