The role of G proteins in the psychobiology and treatment of affective disorders and their integration with the neurotransmitter hypothesis.

Abstract excerpt

Heterotrimeric G proteins are a crucial point of convergence in the transmission of signals from a variety of primary messengers and their membrane receptors to downstream intracellular second messenger effector enzymes and ionic channels. Thus, these proteins have raised increasing interest in the clinical perspective of altered G protein function. This article addresses the most recent significant findings...

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