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Article

Role of structural and sequence information in the prediction of protein stability changes: comparison between buried and partially buried mutations.

Protein engineering - 1 Jul 1999

Gromiha M M, Oobatake M, Kono H, Uedaira H, Sarai A

Abstract excerpt

Predicting mutation-induced changes in protein stability is one of the greatest challenges in molecular biology. In this work, we analyzed the correlation between stability changes caused by buried and partially buried mutations and changes in 48 physicochemical, energetic and conformational properties. We found that properties reflecting hydrophobicity strongly correlated with stability of buried mutations, and...

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PMID: 10436080
DOI: 10.1093/protein/12.7.549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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