Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.

Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003

Comerford Katrina M, Leonard Martin O, Karhausen Jorn, Carey Robyn, Colgan Sean P, Taylor Cormac T

Abstract excerpt

Phosphorylation-dependent ubiquitination combined with proteasomal degradation of transcriptional regulators is a recently appreciated mechanism for control of a number of inflammatory genes. Far less is known about the counterregulatory mechanisms that repress transcriptional activity in these pathways during resolution. Here, we investigated the transient nature of hypoxia-induced tumor necrosis factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Biotinylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Northern

Share to Cyclic AMP Response Element-Binding Protein

Share to Gene Products, tat

Share to Hypoxia

Share to Precipitin Tests

Share to SUMO-1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 12552083
DOI: 10.1073/pnas.0337412100
PMCID: PMC298713

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.PMID 12552083Read ↗

HIF-transcribed p53 chaperones HIF-1αSemantic proximity Read ↗

Translational control of gene expression during hypoxiaSemantic proximity Read ↗

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.Semantic proximity Read ↗

Increased SUMO-1 expression in response to hypoxia: Interaction with HIF-1α in hypoxic pulmonary hypertensionSemantic proximity Read ↗

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein.Semantic proximity Read ↗

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T CellsSemantic proximity Read ↗

Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.Semantic proximity Read ↗

Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1Semantic proximity Read ↗

Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha.Semantic proximity Read ↗

Differential regulation of three members of the ATF/CREB family of DNA-binding proteins.Semantic proximity Read ↗

Regulation of Steroidogenesis and the Steroidogenic Acute Regulatory Protein by a Member of the cAMP Response-Element Binding Protein FamilySemantic proximity Read ↗

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.