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Article

TNFα signals via p66(Shc) to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells.

PloS one - 1 Jan 2013

Laviola Luigi, Orlando Maura Roberta, Incalza Maria Angela, Caccioppoli Cristina, Melchiorre Mariangela, Leonardini Anna, Cignarelli Angelo, Tortosa Federica, Labarbuta Rossella, Martemucci Sabina, Pacelli Consiglia, Cocco Tiziana, Perrini Sebastio, Natalicchio Annalisa, Giorgino Francesco

Abstract excerpt

Endothelial cells participate in inflammatory events leading to atherogenesis by regulating endothelial cell permeability via the expression of VE-Cadherin and β-catenin and leukocyte recruitment via the expression of E-Selectins and other adhesion molecules. The protein p66(Shc) acts as a sensor/inducer of oxidative stress and may promote vascular dysfunction. The objective of this study was to investigate the...

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Identifiers

PMID: 24349153
DOI: 10.1371/journal.pone.0081930
PMCID: PMC3857848

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