Article
Estimation of mutation rate at human glycophorin A locus in hematopoietic stem cell progenitors.
Environmental and molecular mutagenesis - 1 Jan 2002
Vickers M A, Hoy T, Lake H, Kyoizumi S, Boyse J, Hewitt M
Abstract excerpt
Surveys of human mutant cells exhibit a few individuals with relatively high "outlying" values, which might be explained by rare mutations occurring during development. To estimate how commonly this occurs, mutant red cell frequencies at the glycophorin A locus in 135 neonates and 109 children and adolescents from three research centers are compared with simulations in which mutations arise from successive cycles...
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