Article
Modelling haemopoietic stem cell division by analysis of mutant red cells.
British journal of haematology - 1 Jul 2000
Vickers M, Brown G C, Cologne J B, Kyoizumi S
Abstract excerpt
Data describing the number of human red cells mutated at the glycophorin A locus, measured flow cytometrically, are reported for 752 adults and 49 neonates. The variance increases with age more rapidly than the approximately linear increase in mean. It is postulated that this discrepancy is explained by the known property of asymmetric stem cell division, so that the division of a single mutant stem cell may...
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