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Article

Multiple mutant clones in blood rarely coexist.

Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Feb 2008

Dingli David, Pacheco Jorge M, Traulsen Arne

Abstract excerpt

Leukemias arise due to mutations in the genome of hematopoietic (blood) cells. Hematopoiesis has a multicompartment architecture, with cells exhibiting different rates of replication and differentiation. At the root of this process, one finds a small number of stem cells, and hence the description of the mutation-selection dynamics of blood cells calls for a stochastic approach. We use stochastic dynamics to...

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Identifiers

PMID: 18352059
DOI: 10.1103/PhysRevE.77.021915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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