A mutation in the folA promoter delays adaptation to minimal medium by Escherichia coli K-12.

Abstract excerpt

In its natural environment, Escherichia coli is subjected to frequent changes in nutrients and physical parameters such as temperature. Adapting to new conditions requires an orderly progression of events. We show that a folA mutant that overexpressed dihydrofolate reductase because of a C to T promoter mutation, adapted very slowly when transferred from rich medium at 37 degrees C to glucose minimal medium at 42...

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