Article
Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli.
Science (New York, N.Y.) - 22 Jul 1994
Huisman G W, Kolter R
Abstract excerpt
When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli, this process is mediated by the sigma s subunit of RNA polymerase. Expression of sigma s was induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis. Homoserine lactone-dependent synthesis of sigma s was prevented by overexpression of a...
Topics
- 4-Butyrolactone
- Amino Acid Sequence
- Bacterial Proteins
- Catalase
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Models, Biological
- Molecular Sequence Data
- Operon
- Phenotype
- Sigma Factor