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Article

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.

Developmental cell - 1 Jul 2002

Miyamoto Toshihiro, Iwasaki Hiromi, Reizis Boris, Ye Min, Graf Thomas, Weissman Irving L, Akashi Koichi

Abstract excerpt

We demonstrate here that "promiscuous" expression of myeloid or lymphoid genes precedes lineage commitment in hematopoiesis. Prospectively purified single common myeloid progenitors (CMPs) coexpress myelo-erythroid but not lymphoid genes, whereas single common lymphoid progenitors (CLPs) coexpress T and B lymphoid but not myeloid genes. Genes unrelated to the adopted lineage are downregulated in bipotent and...

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Identifiers

PMID: 12110174
DOI: 10.1016/s1534-5807(02)00201-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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