Article
Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A.
Blood - 19 Jul 2018
Buscarlet Manuel, Provost Sylvie, Zada Yassamin Feroz, Bourgoin Vincent, Mollica Luigina, Dubé Marie-Pierre, Busque Lambert
Abstract excerpt
We analyzed DNA from polymorphonuclear (PMN) cells, monocytes, B cells, and T cells of 107 individuals with clonal hematopoiesis of indeterminate potential (CHIP) to perform lineage restriction analysis of different gene mutations. Three lineage categories were defined: myeloid (PMN with or without monocytes), myelolympho-B (myeloid and B cells), and multipotent (myeloid, B and T cells). Six individuals with...
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