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Article

Evaluation of a single-tube multiplex polymerase chain reaction screen for detection of common alpha-thalassemia genotypes in a clinical laboratory.

American journal of clinical pathology - 1 Jul 2002

Bergstrome Jones Alana K, Poon Annette

Abstract excerpt

We prospectively compared a single-tube multiplex polymerase chain reaction (PCR) for detecting alpha-thalassemia with our current approach using 452 blood samples. Initial evaluation of 89 specimens revealed sensitivity and specificity, respectively, for the hemoglobin H inclusion body test (HbH prep) vs PCR for detecting alpha0-thalassemia carriers of 0.79 and 0.96 and for a mean corpuscular volume (MCV) of 82...

Topics

DNA
DNA Primers
Erythrocyte Indices
Genotype
Hemoglobin H
Humans
Mass Screening
Polymerase Chain Reaction
Prospective Studies
Sensitivity and Specificity
alpha-Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12109851
DOI: 10.1309/3VK2-UCJ1-5GBJ-QV8Q

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