Article
Detection of Severe Nondeletional α -Thalassemia Mutations Using a Single-Tube Multiplex ARMS Assay
1 Dec 2001
Abstract excerpt
Alpha-thalassemia is a common hereditary anemia due to decreased or absent synthesis of alpha-globin chains. The most common causes of alpha-thalassemia are deletions that remove one or both functional alpha-globin genes, with a small proportion of cases involving nondeletional mutations of the alpha2- or alpha1-globin genes. Herein, we describe a single-tube multiplex amplification refractory mutation system...
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