Article
Rapid differentiation of five common alpha-thalassemia genotypes by polymerase chain reaction.
The Journal of laboratory and clinical medicine - 1 Apr 2001
Tang D C, Fucharoen S, Ding I, Rodgers G P
Abstract excerpt
The alpha-thalassemias are common genetic disorders that arise from reduced synthesis of the alpha-globin chains. At present, large-scale carrier screening and clinically valuable antenatal detection programs have not been established for the congenital disorder alpha-thalassemia (alpha-thal). We have developed a simple nonradioactive polymerase chain reaction (PCR) approach that can detect and differentiate...
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