Article
Improvement of alpha(0)-thalassemia screening using combined osmotic fragility, dichlorophenolindophenol and Hb H inclusion tests.
Clinical laboratory - 1 Jan 2010
Chaibunruang Attawut, Pornphannukool Sontong, Sae-Ung Nattaya, Fucharoen Goonnapa, Sanchaisuriya Kanokwan, Fucharoen Supan
Abstract excerpt
BACKGROUND: Screening for alpha(0)-thalassemia is usually done using osmotic fragility (OF) test or reduced erythrocyte indexes, both with high sensitivity, but accurate diagnosis requires PCR analysis. However, a low specificity of screening leads to unnecessary PCR workload during a massive population survey. We have established a more effective screening strategy using a combination of three simple tests....
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