Article
Feasibility of molecular diagnosis of alpha-thalassemia in the evaluation of microcytosis.
Haematologica - 1 Jan 2000
Sivera P, Roetto A, Mazza U, Camaschella C
Abstract excerpt
Microcytosis is a common hematological finding, usually related to iron deficiency or beta-thalassemia. When both of these conditions are excluded, alpha-thalassemia must be considered in the differential diagnosis. No simple biochemical test is able to diagnose the alpha-thalassemia trait. Using PCR amplification of the breakpoint in deletional forms, and amplification of the alpha 2 gene and restriction enzyme...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.