Article
Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.
Cancer chemotherapy and pharmacology - 1 Sept 2003
Kanovsky Mecheal, Michl Josef, Botzolaki Georgia, Morin Joseph, Kovac Cecilia, Chung Denise L, Chie Lyndon, Friedman Fred K, Pincus Matthew R
Abstract excerpt
PURPOSE: From molecular modeling studies we found that two ras-p21 peptides, corresponding to p21 residues 35-47 (PNC-7) and 96-110 (PNC-2), selectively block oncogenic (Val 12-p21), but not insulin-activated wild-type, p21-induced oocyte maturation. Our purpose was to determine if these peptides block the growth of mammalian cancer cells but not their normal counterpart cells. METHODS: Since oncogenic ras has...
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