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Article

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.

Molecular and cellular biology - 1 Aug 2002

Rogoff Harry A, Pickering Mary T, Debatis Michelle E, Jones Stephen, Kowalik Timothy F

Abstract excerpt

It has been proposed that the E2F1 transcription factor serves as a link between the Rb/E2F proliferation pathway and the p53 apoptosis pathway by inducing the expression of p19ARF, a protein that regulates p53 stability. We find that although p19ARF contributes to p53 accumulation in response to E2F expression, p19ARF is not required for E2F1-mediated apoptosis. E2F1 can signal p53 phosphorylation in the absence...

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Identifiers

PMID: 12101227
DOI: 10.1128/MCB.22.15.5308-5318.2002
PMCID: PMC133953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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