Article
A novel autoimmune pancreatitis model in MRL mice treated with polyinosinic:polycytidylic acid.
Clinical and experimental immunology - 1 Jul 2002
Qu W-M, Miyazaki T, Terada M, Okada K, Mori S, Kanno H, Nose M
Abstract excerpt
In this study we established a new animal model for exploring the pathogenesis of autoimmune pancreatitis. We have found previously that MRL/Mp-+/+(MRL/+) mice develop pancreatitis spontaneously by an autoimmune mechanism but only when they are more than 34 weeks old. Because this disease might be a model of multi-factorial diseases controlled by genetic and environmental factors, beginning at 6 weeks old, we...
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