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Article

p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.

The Journal of biological chemistry - 20 Feb 2004

Vasseur Sophie, Folch-Puy Emma, Hlouschek Verena, Garcia Stephane, Fiedler Fritz, Lerch Markus M, Dagorn Jean Charles, Closa Daniel, Iovanna Juan Lucio

Abstract excerpt

p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis. A p8-deficient mouse strain was generated as a tool to investigate its function. Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in...

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PMID: 14660681
DOI: 10.1074/jbc.M309152200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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