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Article

Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors.

Cancer research - 1 Jul 2002

Morán Alberto, Iniesta Pilar, de Juan Carmen, González-Quevedo Rosa, Sánchez-Pernaute Andrés, Díaz-Rubio Eduardo, Ramón y Cajal Santiago, Torres Antonio, Balibrea Jose Luis, Benito Manuel

Abstract excerpt

Colorectal cancers from the mutator phenotype pathway display distinctive pathological features and confer a lesser aggressiveness than colorectal adenocarcinomas originated by the suppressor pathway. The goal of this work was to test whether tumors developed through the mutator pathway could show a decrease in matrix metalloproteinase (MMP) activity. We evaluated levels and activity of gelatinase A (MMP-2) and...

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PMID: 12097300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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