Stromal expression of invasion‐promoting, matrix‐degrading proteases MMP‐1 and ‐9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers

Abstract excerpt

Hereditary nonpolyposis colorectal cancers (HNPCCs) are an important subgroup of colorectal carcinomas. Compared to sporadic variants, they present several particular features, the most important of which are less invasive and metastatic properties linked to a more favorable prognosis. This contrasts to the generally poor differentiation of the epithelial tumor component. Since matrix-degrading proteases secreted...

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