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Article

Impairment of stromelysin-1 transcriptional activity by promoter mutations in high microsatellite instability colorectal tumors.

Cancer research - 1 May 2005

Morán Alberto, Iniesta Pilar, de Juan Carmen, García-Aranda Cristina, Díaz-López Antonio, Benito Manuel

Abstract excerpt

Colorectal tumorigenesis is characterized by the sequential inactivation of a series of tumor suppressor genes (microsatellite-stable tumors) and genetic or epigenetic alterations in mismatch repair genes in nonpoliposic hereditary tumours and 13% to 15% of sporadic colorectal cancer [high microsatellite instability (MSI-H) tumors]. We hypothesized a molecular mechanism for MSI-H colorectal tumors related to...

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PMID: 15867378
DOI: 10.1158/0008-5472.CAN-04-4442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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