Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer

1 Jan 2013

Abstract excerpt

DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in cancer development. Gene silencing via CpG island methylation/demethylation in the promoter region is one of the mechanisms by which different genes are inactivated/activated in human cancers. Tissue inhibitor of metalloproteinase-2 (TIMP-2) is known to antagonize matrix...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Peptidase Inhibition and Analysis
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23661436
DOI: 10.4238/2013.april.10.6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancerPMID 23661436Read ↗

Epigenetic Control of the Invasion-promoting MT1-MMP/MMP-2/TIMP-2 Axis in Cancer CellsSemantic proximity Read ↗

Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironmentSemantic proximity Read ↗

Frequent hypermethylation of 5' flanking region of TIMP-2 gene in cervical cancer.Semantic proximity Read ↗

Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancerSemantic proximity Read ↗

S-adenosylmethionine inhibits the activated phenotype of human hepatic stellate cells via Rac1 and matrix metalloproteinases.Semantic proximity Read ↗

The behavior of matrix metalloproteinases and their inhibitors in colorectal cancer.Semantic proximity Read ↗

TIMP‐1 expression in human colorectal cancer is associated with TGF‐B1, LOXL2, INHBA1, TNF‐AIP6 and TIMP‐2 transcript profilesSemantic proximity Read ↗

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.Semantic proximity Read ↗

Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells <i>via</i> inhibition of JAK2/STAT3/STAT5 signallingSemantic proximity Read ↗

Tissue inhibitor of matrix metalloproteinase‐1 expression in colorectal cancer liver metastases is associated with vascular structuresSemantic proximity Read ↗

Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.Semantic proximity Read ↗

The Role of Tissue Factor Pathway Inhibitor-2 in Cancer BiologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.