Article
Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma.
Human genetics - 1 Sept 2012
Liu Yanhong, Melin Beatrice S, Rajaraman Preetha, Wang Zhaoming, Linet Martha, Shete Sanjay, Amos Christopher I, Lau Ching C, Scheurer Michael E, Tsavachidis Spiridon, Armstrong Georgina N, Houlston Richard S, Hosking Fay J, Claus Elizabeth B, Barnholtz-Sloan Jill, Lai Rose, Il'yasova Dora, Schildkraut Joellen, Sadetzki Siegal, Johansen Christoffer, Bernstein Jonine L, Olson Sara H, Jenkins Robert B, LaChance Daniel, Vick Nicholas A, Wrensch Margaret, Davis Faith, McCarthy Bridget J, Andersson Ulrika, Thompson Patricia A, Chanock Stephen, Bondy Melissa L
Abstract excerpt
The risk of glioma has consistently been shown to be increased twofold in relatives of patients with primary brain tumors (PBT). A recent genome-wide linkage study of glioma families provided evidence for a disease locus on 17q12-21.32, with the possibility of four additional risk loci at 6p22.3, 12p13.33-12.1, 17q22-23.2, and 18q23. To identify the underlying genetic variants responsible for the linkage signals,...
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