Article
Cytokine gene polymorphism and heart transplant rejection.
Transplantation - 15 Sept 1997
Turner D, Grant S C, Yonan N, Sheldon S, Dyer P A, Sinnott P J, Hutchinson I V
Abstract excerpt
BACKGROUND: Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. METHODS: We have related polymorphisms that influence cytokine production in the tumor necrosis factor (TNF)-A and interleukin (IL)-10 genes to early graft rejection in 115 heart...
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