Article
A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration.
The EMBO journal - 21 Dec 2005
Ferguson Kerry L, McClellan Kelly A, Vanderluit Jacqueline L, McIntosh William C, Schuurmans Carol, Polleux Franck, Slack Ruth S
Abstract excerpt
Precise cell cycle regulation is critical for nervous system development. To assess the role of the cell cycle regulator, retinoblastoma (Rb) protein, in forebrain development, we studied mice with telencephalon-specific Rb deletions. We examined the role of Rb in neuronal specification and migration of diverse neuronal populations. Although layer specification occurred at the appropriate time in Rb mutants,...
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