Article
K-RAS mutation in transitional cell carcinoma of urinary bladder.
International urology and nephrology - 1 Jan 2001
Ayan S, Gokce G, Kilicarslan H, Ozdemir O, Yildiz E, Gultekin E Y
Abstract excerpt
In the present study it was aimed to investigate the frequency of K-RAS mutation in the human bladder transitional cell carcinoma. For this purpose, tissue specimens obtained from the patients with bladder tumors. Genomic DNAs were isolated and then PCR-SSCP analysis of K-RAS gene were performed. A heterozygous deleted mutation was detected in K-RAS oncogene (exon 2) in agarose gel electrophoresis in one patient...
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