Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of recombinant FV Hong Kong and FV Cambridge

15 Jul 2002

Abstract excerpt

In factor V (FV) Cambridge (Arg306Thr) and Hong Kong (Arg306Gly), a cleavage site for anticoagulant activated protein C (APC), which is crucial for the inactivation of FVa, is lost. Although patients carrying FV Hong Kong have a normal APC response, those with FV Cambridge were reported to be APC resistant. To elucidate the molecular characteristics of the 2 FV mutants, we recreated them in a recombinant system...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Structural Anomalies and Repair

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12091344
DOI: 10.1182/blood-2002-02-0343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Functional characterization of recombinant FV Hong Kong and FV CambridgePMID 12091344Read ↗

Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population.Semantic proximity Read ↗

A Thai patient with the mutation of Arg306 of FV gene identical to the Hong Kong but not to the Cambridge type.Semantic proximity Read ↗

Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.Semantic proximity Read ↗

Novel APC-cleavage sites in FVa provide insights into mechanisms of action of APC and its cofactor protein S.Semantic proximity Read ↗

The R306G and R506Q mutations in coagulation Factor V reveals additional cleavage sites for Activated Protein C in the R313-R321 region and at R505.Semantic proximity Read ↗

Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.Semantic proximity Read ↗

A novel mutation of Arg306 of factor V gene in Hong Kong Chinese.Semantic proximity Read ↗

Factor V Cambridge: a new mutation (Arg306-->Thr) associated with resistance to activated protein C.Semantic proximity Read ↗

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.Semantic proximity Read ↗

Primary thrombophilia in Mexico IV: frequency of the Leiden, Cambridge, Hong Kong, Liverpool and HR2 haplotype polymorphisms in the factor V gene of a group of thrombophilic Mexican Mestizo patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.