Article
An essential role for peptidergic signalling in the control of circadian rhythms in the suprachiasmatic nuclei.
Journal of neuroendocrinology - 1 Apr 2003
Harmar A J
Abstract excerpt
Two structurally related neuropeptides, pituitary adenylate cyclase-activating polypeptide (PACAP), colocalized with glutamate in neurones of the retinohypothalamic tract, and vasoactive intestinal peptide (VIP), present in light-responsive cells of the suprachiasmatic nuclei (SCN), appear to play distinct and important roles in the control of mammalian circadian rhythms. Mice deficient in the PACAP-selective...
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