Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MIF Maintains the Tumorigenic Capacity of Brain Tumor–Initiating Cells by Directly Inhibiting p53

16 Mar 2016

Abstract excerpt

Tumor-initiating cells thought to drive brain cancer are embedded in a complex heterogeneous histology. In this study, we isolated primary cells from 21 human brain tumor specimens to establish cell lines with high tumorigenic potential and to identify the molecules enabling this capability. The morphology, sphere-forming ability upon expansion, and differentiation potential of all cell lines were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apelin-related biomedical research
Share to Macrophage Migration Inhibitory Factor
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26980763
DOI: 10.1158/0008-5472.can-15-1011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MIF Maintains the Tumorigenic Capacity of Brain Tumor–Initiating Cells by Directly Inhibiting p53PMID 26980763Read ↗

Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression.Semantic proximity Read ↗

Brain Metastasis-Initiating Cells: Survival of the FittestSemantic proximity Read ↗

HGF/MET Signaling in Malignant Brain TumorsSemantic proximity Read ↗

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.Semantic proximity Read ↗

RNAi screen identifies essential regulators of human brain metastasis-initiating cellsSemantic proximity Read ↗

The Ser/Thr kinase MAP4K4 drives c-Met-induced motility and invasiveness in a cell-based model of SHH medulloblastomaSemantic proximity Read ↗

Cytoplasmic localization of wild-type p53 in glioblastomas correlates with expression of vimentin and glial fibrillary acidic protein.Semantic proximity Read ↗

miR-192 suppresses leptomeningeal dissemination of medulloblastoma by modulating cell proliferation and anchoring through the regulation ofDHFR, integrins, andCD47Semantic proximity Read ↗

p53 and brain tumors: from gene mutations to gene therapy.Semantic proximity Read ↗

Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growthSemantic proximity Read ↗

Establishment and characterization of a new human glioblastoma cell line (MGM-1) with highly motile phenotype.Semantic proximity Read ↗

Bmi1 and cell of origin determinants of brain tumor phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.