Article
The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma.
The Journal of allergy and clinical immunology - 1 Feb 2000
Liggett S B
Abstract excerpt
The beta(2)-adrenergic receptor (beta(2)AR) is the molecular target for beta-agonists used in the treatment of asthma. In the human population, 4 polymorphisms of the beta(2)AR coding block have been found, 3 of which result in receptors that have different properties compared with wild-type. To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to...
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