Article
Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.
Oncogene - 9 May 2002
Blanco Maria J, Moreno-Bueno Gema, Sarrio David, Locascio Annamaria, Cano Amparo, Palacios José, Nieto M Angela
Abstract excerpt
Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a series of human breast carcinomas, we have analysed the expression of Snail and that of...
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