Article
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Cancer research - 1 Jun 1997
Moskaluk C A, Hruban R H, Kern S E
Abstract excerpt
Pancreatic adenocarcinoma is thought to arise from a noninvasive neoplastic precursor, the pancreatic intraductal lesion (PIL). Mutations of the K-ras gene are known to occur in PILs, but their high prevalence among PILs within the general population probably limit the use of K-ras as a marker of eventual clinical risk. In search of genetic constellations that might indicate the progression of some PILs toward an...
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