Article
A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis.
Kidney international - 1 Jul 2002
Rovin Brad H, Lu Ling, Zhang Xiaolan
Abstract excerpt
BACKGROUND: Interleukin-8 (IL-8) is a potent neutrophil chemokine that has been implicated in the pathogenesis of renal inflammation in human glomerulonephritis. To explain inter-patient variations in renal inflammation during diseases such as systemic lupus erythematosus (SLE), it was postulated that the promoter region of the IL-8 gene contains polymorphic residues that influence the level of IL-8 expression in...
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