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Promoter Methylation of <i>TSLC1</i> and Tumor Suppression by Its Gene Product in Human Prostate Cancer

1 Jun 2002

Abstract excerpt

We recently identified TSLC1, a tumor suppressor gene in human lung cancer. Gene silencing by promoter methylation has been observed frequently in adenocarcinoma of the lung, liver, and pancreas. Here, we demonstrate that TSLC1 expression is also absent or markedly reduced in 3 of 4 prostate cancer cell lines. Promoter sequences of TSLC1 were heavily methylated in PPC-1 cells that lacked TSLC1 expression,...

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PMID: 12079507
DOI: 10.1111/j.1349-7006.2002.tb01297.x

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