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Article

Genetic and epigenetic inactivation of <i>LPL</i> gene in human prostate cancer

2 Sept 2008

Abstract excerpt

Lipoprotein lipase (LPL) is in chromosome 8p22, site of one of the most common somatic deletions in prostate tumors. Additionally, a CpG island (CGI) was identified in the LPL promoter region. To test the hypothesis that LPL is a tumor suppressor gene, which is inactivated by somatic deletion and hypermethylation in prostate cancer, we evaluated somatic DNA deletion and methylation status at LPL in 56 pairs of...

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Identifiers

PMID: 19004026
DOI: 10.1002/ijc.23972

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