Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypermethylation of the <i>TSLC1/IGSF4</i> promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma

13 Mar 2006

Abstract excerpt

BACKGROUND: The tumor suppressor gene TSLC1/IGSF4 on chromosomal region 11q23 is frequently inactivated by promoter methylation in various cancers, including nonsmall cell lung carcinoma (NSCLC). Several studies have demonstrated that the hypermethylation of the CpG islands of genes, including tumor suppressors, is associated with exposure to tobacco smoke. The purpose of this study was to investigate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood properties and coagulation
Share to Caveolin-1 and cellular processes
Share to Erythrocyte Function and Pathophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16534787
DOI: 10.1002/cncr.21800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypermethylation of the <i>TSLC1/IGSF4</i> promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinomaPMID 16534787Read ↗

Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines.Semantic proximity Read ↗

SCT promoter methylation is a highly discriminative biomarker for lung and many other cancersSemantic proximity Read ↗

Reduced expression of the Tslc1 gene and its aberrant DNA methylation in rat lung tumors.Semantic proximity Read ↗

Aberrant Promoter Methylation Profile and Association with Survival in Patients with Non–Small Cell Lung CancerSemantic proximity Read ↗

Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines.Semantic proximity Read ↗

Association of RASSF1A promoter methylation with lung cancer risk: a meta-analysis.Semantic proximity Read ↗

Aberrant Methylation of the 5' CpG Island of TSLC1 Is Common in Pancreatic Ductal Adenocarcinoma and Is First Manifest in High-Grade PanINsSemantic proximity Read ↗

Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokersSemantic proximity Read ↗

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.Semantic proximity Read ↗

Expression of <i>TSLC1</i>, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylationSemantic proximity Read ↗

Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status.Semantic proximity Read ↗

Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.