Article
GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells.
The American journal of pathology - 1 Nov 2001
Lin X, Tascilar M, Lee W H, Vles W J, Lee B H, Veeraswamy R, Asgari K, Freije D, van Rees B, Gage W R, Bova G S, Isaacs W B, Brooks J D, DeWeese T L, De Marzo A M, Nelson W G
Abstract excerpt
GSTP1 CpG island hypermethylation is the most common somatic genome alteration described for human prostate cancer (PCA); lack of GSTP1 expression is characteristic of human PCA cells in vivo. We report here that loss of GSTP1 function may have been selected during the pathogenesis of human PCA. Using a variety of techniques to detect GSTP1 CpG island DNA hypermethylation in PCA DNA, we found only hypermethylated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.