Article
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis.
Molecular and cellular biology - 1 Jul 2002
Roy Sandrine, Wyse Bruce, Hancock John F
Abstract excerpt
Endocytosis is required for efficient mitogen-activated protein kinase (MAPK) activation by activated growth factor receptors. We examined if H-Ras and K-Ras proteins, which are distributed across different plasma membrane microdomains, have equal access to the endocytic compartment and whether this access is necessary for downstream signaling. Inhibition of endocytosis by dominant interfering dynamin-K44A...
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